Scientific Publications

Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity. Patil Y, Amitay Y, Ohan P, Shmeeda H, Gabizon A. J Control Release 225:87-95, 2016

 

Preclinical Evaluation of Promitil, A Novel Nanoparticle Formulation of Mitomycin C, in Chemoradiation Therapy.Tian X, Nabeel H, Wagner KT, Nguyen M, Min Y, Sethi M, and Wang AZ. International Journal of Radiation Oncology, 90 (1):S803, 2014.
http://www.redjournal.org/article/S0360-3016%2814%2902969-1/fulltext

 

Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy. Tian X, Warner SB, Wagner KT, Caster JM, Zhang T, Ohana P, Gabizon AA, Wang AZ. Int J Radiat Oncol Biol Phys.;96(3):547-55, 2016

 

Pharmacologic Studies of a Prodrug of Mitomycin C in Pegylated Liposomes (Promitil®): High Stability in Plasma and Rapid Thiolytic Prodrug Activation in Tissues. Amitay Y, Shmeeda H, Patil Y, Gorin J, Tzemach D, Mak L, Ohana P, Gabizon A. Pharm Res - 33(3): 686-700, 2016

 

Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients Golan T , Grenader T, Ohana  P, Amitay Y, Shmeeda H, La-Beck  NM, Tahover E , Berger R & Gabizon AA Cancer Medicine 4(10): 1472-83, 2015

 

Therapeutic efficacy of a lipid-based prodrug of mitomycin C in pegylated liposomes: studies with human gastro-entero-pancreatic ectopic tumor models. Gabizon A, Amitay Y, Tzemach D, Gorin J, Shmeeda H, Zalipsky S. J Control Release, 160(2):245-53, 2012.

 

Antitumor activity of new liposomal prodrug of mitomycin C in multidrug resistant solid tumor: insights of the mechanism of action. Zalipsky S, Saad M, Kiwan R, Ber E, Yu N, Minko T. J Drug Target, 15(7-8):518-30, 2007.

 

Reduced toxicity and superior therapeutic activity of a mitomycin C lipid-based prodrug incorporated in pegylated liposomes. Gabizon AA, Tzemach D, Horowitz AT, Shmeeda H, Yeh J, Zalipsky S. Clin Cancer Res, 12(6):1913-20, 2006.